Para dores cronicas - PEA (Palmitoiletanolamida)

<p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><span style="font-size:22px;"><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; line-height: 1.5; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; font-family: var(--q-font-primary) !important;">PEA Palmitoiletanolamida</span></u></span></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">A palmitoiletanolamida (N-Palmitoiletanolamida ou PEA) &eacute; uma amida de &aacute;cido graxo end&oacute;gena pertencente &agrave; classe da N-aciletanolamida (NAE) de mol&eacute;culas sinalizadoras, produzida a partir da bicamada lip&iacute;dica e tamb&eacute;m est&aacute; presente em alimentos como ovo e o amendoim. A descoberta dessa classe ocorreu na d&eacute;cada de 1940, quando pesquisadores suplementaram a dieta de crian&ccedil;as carentes com gema de ovo em p&oacute;, prevenindo assim a febre reum&aacute;tica. Por&eacute;m, somente em 1957 a palmitoiletanolamida foi isolada e teve comprovada sua a&ccedil;&atilde;o anti-inflamat&oacute;ria.&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Contudo, foi na d&eacute;cada de 1990 que seu mecanismo de a&ccedil;&atilde;o foi elucidado, quando foi proposto que a PEA seria uma subst&acirc;ncia reguladora end&oacute;gena do processo inflamat&oacute;rio, rendendo um Nobel de Medicina para o grupo de Rita Levi-Montalcini. O sistema endocanabinoide, do qual PEA faz parte, &eacute; formado por mediadores end&oacute;genos e pelos receptores de membrana celular, presentes em grande quantidade no sistema nervoso central, surgiu recentemente como uma nova estrat&eacute;gia terap&ecirc;utica para o manejo da dor cr&ocirc;nica.&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Estudos demonstraram a efic&aacute;cia no tratamento da dor cr&ocirc;nica de origem neurop&aacute;tica e inflamat&oacute;ria, dessa forma introduzindo uma nova alternativa na terapia analg&eacute;sica e anti-inflamat&oacute;ria. Atualmente diversos estudos cl&iacute;nicos demonstram o potencial terap&ecirc;utico da PEA no tratamento da dor e da inflama&ccedil;&atilde;o, especialmente em processos cr&ocirc;nicos degenerativos.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Os efeitos anti-inflamat&oacute;rios e analg&eacute;sicos s&atilde;o dose-dependentes e t&ecirc;m sido confirmados em modelos de inflama&ccedil;&atilde;o cr&ocirc;nica e dor neurop&aacute;tica. Nesses modelos o tratamento n&atilde;o apenas reduziu a dor, mas tamb&eacute;m preservou a morfologia perif&eacute;rica do nervo, reduziu o edema endoneural, o recrutamento e ativa&ccedil;&atilde;o de mast&oacute;citos e a produ&ccedil;&atilde;o de mediadores inflamat&oacute;rios no local da les&atilde;o. Esses dados indicam que PEA pode agir como um agende modificador da doen&ccedil;a. Um crescente n&uacute;mero de estudos cl&iacute;nicos confirmam que PEA proporciona o al&iacute;vio da dor em diferentes condi&ccedil;&otilde;es de dor cr&ocirc;nica.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Evid&ecirc;ncias Cl&iacute;nicas no Manejo da Dor</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Nas triagens cl&iacute;nicas avaliando a efic&aacute;cia e seguran&ccedil;a, a administra&ccedil;&atilde;o foi realizada por per&iacute;odos variando entre 14 e 120 dias, com doses variando entre 300 e 1200 mg ao dia. A forma mais comum de avalia&ccedil;&atilde;o foi a VAS (Visual Analogue Scale), em que o paciente faz uma avalia&ccedil;&atilde;o subjetiva do n&iacute;vel de dor em uma escala variando de aus&ecirc;ncia de dor at&eacute; a pior dor imagin&aacute;vel.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Conclus&otilde;es:&nbsp;<span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">&nbsp;</span>Os resultados de todas as triagens cl&iacute;nicas, envolvendo no total, cerca de 6.000 pacientes demonstraram a redu&ccedil;&atilde;o da intensidade de dor e a aus&ecirc;ncia de efeitos adversos. Portanto, PEA representa uma nova estrat&eacute;gia terap&ecirc;utica no manejo da dor cr&ocirc;nica e dor neurop&aacute;tica associada com a neuroinflama&ccedil;&atilde;o, geralmente bem tolerado nas popula&ccedil;&otilde;es pesquisadas, sem nenhum efeito adverso espec&iacute;fico reportado.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Doen&ccedil;as Neurodegenerativas</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">&nbsp;</span>A maior parte das pesquisas com PEA est&aacute; relacionada ao manejo da dor e condi&ccedil;&otilde;es inflamat&oacute;rias perif&eacute;ricas, enquanto ainda s&atilde;o muito poucas pesquisas com objetivo de avaliar poss&iacute;veis efeitos ben&eacute;ficos em patologias relacionadas ao SNC.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Doen&ccedil;a de Alzheimer</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Estudos pr&eacute;-cl&iacute;nicos t&ecirc;m demonstrado que o PEA pode ser um potencial agente terap&ecirc;utico em doen&ccedil;as que provocam neurodegenera&ccedil;&atilde;o. Tem demonstrado potencial efeito neuroprotetor em modelos de Doen&ccedil;a de Alzheimer (DA). A neuroinflama&ccedil;&atilde;o e a disfun&ccedil;&atilde;o sin&aacute;ptica em DA tem sido originalmente considerada um epifen&ocirc;meno com inflama&ccedil;&atilde;o e altera&ccedil;&atilde;o na neurotransmiss&atilde;o, ocorrendo quando neur&ocirc;nios danificados provocam altera&ccedil;&otilde;es na glia e mudan&ccedil;as na biologia neuronal.&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Atualmente est&aacute; claramente estabelecido que a fisiopatologia da DA inclui tamb&eacute;m intera&ccedil;&otilde;es com mecanismos imunol&oacute;gicos no SNC. A neuroinflama&ccedil;&atilde;o na DA est&aacute; predominantemente relacionada com a microglia e astroglia residentes no SNC e com macr&oacute;fagos perivasculares. As respostas inflamat&oacute;rias regionais caracterizam o SNC na DA, com dep&oacute;sito de&nbsp;<span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: Symbol; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">b</span>-amiloide associada com o aumento da express&atilde;o de citoquinas pr&oacute;-inflamat&oacute;rias, prote&iacute;nas de fase aguda e componentes do complemento, com sinais de microglia ativada e astr&oacute;citos reativos.&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">De acordo com este cen&aacute;rio, estudos neuropatol&oacute;gicos em c&eacute;rebros humanos, demonstrando a ativa&ccedil;&atilde;o das c&eacute;lulas gliais, principalmente microglia e astr&oacute;citos, tem corroborado com estudos da DA em modelo animal nos quais a superprodu&ccedil;&atilde;o de sinais pro-inflamat&oacute;rios pelas c&eacute;lulas gliais deflagra a cascata neurodegenerativa. Por outro lado, evid&ecirc;ncias indicam que tamb&eacute;m o estresse oxidativo e a disfun&ccedil;&atilde;o sin&aacute;ptica s&atilde;o eventos precoces na DA.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Assim a neuroinflama&ccedil;&atilde;o, o estresse oxidativo e a disfun&ccedil;&atilde;o sin&aacute;ptica s&atilde;o partes integrantes da patog&ecirc;nese da DA. Neste contexto, a sinaliza&ccedil;&atilde;o endocanabinoide e compostos canabinomim&eacute;ticos tem demonstrado modular os principais processos patol&oacute;gicos durante fase precoce da DA, como desnatura&ccedil;&atilde;o de prote&iacute;nas, neuroinflama&ccedil;&atilde;o, disfun&ccedil;&atilde;o mitocondrial e estresse oxidativo. Entre estes compostos, PEA tem atra&iacute;do muita aten&ccedil;&atilde;o porque exerce uma fun&ccedil;&atilde;o local anti les&atilde;o atrav&eacute;s da modula&ccedil;&atilde;o negativa de mast&oacute;citos e protege neur&ocirc;nios de excitotoxicidade por v&aacute;rios mecanismos.&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Os achados descritos aliados aos mecanismos celulares e moleculares descobertos e descritos na &uacute;ltima d&eacute;cada sugerem fortemente que PEA &reg; poderia exercer promissoras fun&ccedil;&otilde;es protetoras contrapondo a neuroinflama&ccedil;&atilde;o e neurodegenera&ccedil;&atilde;o. A habilidade de PEA de interagir sinergicamente por v&aacute;rios mecanismos &eacute; atribu&iacute;da as propriedades &uacute;nicas deste ingrediente nutrac&ecirc;utico em rela&ccedil;&atilde;o a outros f&aacute;rmacos anti-inflamat&oacute;rios convencionais. N&atilde;o existem ainda dados cl&iacute;nicos sobre os efeitos ben&eacute;ficos de PEA em DA, por&eacute;m em um estudo de caso, um paciente de 67 anos com dist&uacute;rbio cognitivo moderado foi tratado com doses altas por 9 meses, com 3 meses de tratamento j&aacute; apresentou melhora no quadro e com 9 meses estava praticamente normal.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Doen&ccedil;a de Parkinson</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Um estudo cl&iacute;nico com 30 pacientes com Parkinson utilizando Levodopa, passaram a receber PEA&nbsp;<span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">&nbsp;</span>na dose de 600 mg ao dia em associa&ccedil;&atilde;o e ap&oacute;s 1 ano demonstraram significativa redu&ccedil;&atilde;o na progress&atilde;o da doen&ccedil;a e na incapacidade f&iacute;sica.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Depress&atilde;o</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">A maioria dos antidepressivos apresentam um limitado &iacute;ndice de resposta e um importante atraso no estabelecimento da a&ccedil;&atilde;o, por esses motivos &eacute; uma &aacute;rea de constantes pesquisas de novos alvos farmacol&oacute;gicos antidepressivos. Evid&ecirc;ncias pr&eacute;-cl&iacute;nicas t&ecirc;m demonstrado que o sistema endocanabin&oacute;ide tem importante papel na modula&ccedil;&atilde;o do humor e resposta ao estresse. O nutrac&ecirc;utico PEA tem como alvos farmacol&oacute;gicos n&atilde;o apenas o receptor PPAR-alfa, mas tamb&eacute;m o GPRR55, um receptor canabin&oacute;ide n&atilde;o CB1 / CB2, pertencente ao sistema endocanabin&oacute;ide. O PEA end&oacute;geno encontra-se aumentado em situa&ccedil;&otilde;es de estresse e em um estudo cl&iacute;nico randomizado, a suplementa&ccedil;&atilde;o de PEA&nbsp;<span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">&nbsp;</span>em associa&ccedil;&atilde;o a terapia com Citalopram, indicou o estabelecimento da a&ccedil;&atilde;o antidepressiva mais r&aacute;pido no grupo com a ado&ccedil;&atilde;o do nutrac&ecirc;utico. Este resultado demonstra efeito antidepressivo promissor de PEA&nbsp;<span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">&nbsp;</span>embora mais estudos sejam necess&aacute;rios para o estabelecimento de seu potencial como modulador de humor e biomarcador de depress&atilde;o.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Coadjuvante no Transtorno do Espectro do Autista (TEA)</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">A inflama&ccedil;&atilde;o assim como a excitotoxicidade do glutamato tem sido considerada pela participa&ccedil;&atilde;o na propaga&ccedil;&atilde;o do transtorno do espectro autista (TEA). PEA&nbsp;<span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">&nbsp;</span>&eacute; um endocanabin&oacute;ide que previne a toxicidade glutamat&eacute;rgica e tamb&eacute;m inibe a resposta inflamat&oacute;ria. Khalaj M. e colaboradores, publicaram em 2018 um primeiro estudo cl&iacute;nico randomizado, duplo-cego, placebo-controlado em grupo-paralelo, realizado por com 70 crian&ccedil;as com idades entre 4 e 12 anos com sintomas moderados a severos de irritabilidade que avaliou a associa&ccedil;&atilde;o de PEA na dose de 600 mg 2 vezes ao dia, ao tratamento estabelecido com Risperidona, por 10 semanas.&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Os resultados demonstraram significativa melhora no grupo utilizando a PEA associado em compara&ccedil;&atilde;o ao grupo controle, especialmente nos par&acirc;metros de irritabilidade e hiperatividade. De acordo com o estudo de Aron A. e colaboradores, publicado em 2019, foi observado n&iacute;veis mais baixos de endocanabinoides como AEA, OEA (N-oleoiletanolamina), e PEA em amostras de soro de 93 crian&ccedil;as com TEA em compara&ccedil;&atilde;o com amostras de neurot&iacute;picos correspondentes ao grupo controle.&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;Essas descobertas est&atilde;o de acordo com os resultados de numerosos estudos anteriores em modelos animais de TEA e estudos iniciais em humanos. Recentemente em 2021, Colizzi M. e colaboradores publicaram a primeira revis&atilde;o sistem&aacute;tica de todos os estudos que exploram os correlatos biocomportamentais do PEA no transtorno do espectro do autismo (TEA) em humanos e animais. Como resultado da suplementa&ccedil;&atilde;o de PEA em humanos como monoterapia e terapia adicional &agrave; medica&ccedil;&atilde;o antipsic&oacute;tica demonstrou reduzir a gravidade geral do autismo melhorando a linguagem expressiva (o que a crian&ccedil;a diz) e fala inadequada (como a crian&ccedil;a fala), al&eacute;m de modular o comportamento at&iacute;pico e a resposta imune.&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Da mesma forma, a suplementa&ccedil;&atilde;o de PEA em diferentes modelos animais de autismo e condi&ccedil;&otilde;es relacionadas foi sugerida como eficaz na melhoria de comportamentos sociais e n&atilde;o sociais, bem como na modula&ccedil;&atilde;o de uma s&eacute;rie de processos neurobiol&oacute;gicos, incluindo neuroinflama&ccedil;&atilde;o, neurotrofia, apoptose, neurog&ecirc;nese, neuroplasticidade, neurodegenera&ccedil;&atilde;o, fun&ccedil;&atilde;o mitocondrial e atividade da microbiota. Possivelmente essas respostas ocorrem atrav&eacute;s da ativa&ccedil;&atilde;o do PPAR-&alpha;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Permeabilidade intestinal</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">PEA modula a permeabilidade intestinal em condi&ccedil;&otilde;es normais e condi&ccedil;&otilde;es inflamat&oacute;rias. PEA diminui a permeabilidade, ou seja, aumenta a resist&ecirc;ncia via PPAR-&alpha;. Os n&iacute;veis celulares de PEA &eacute; aumentado nas c&eacute;lulas epiteliais intestinais em resposta &agrave; inflama&ccedil;&atilde;o, o que pode limitar o aumento da permeabilidade associada &agrave; inflama&ccedil;&atilde;o. Os efeitos ben&eacute;ficos sobre a permeabilidade intestinal podem, pelo menos parcialmente, fundamentar o efeito protetor da PEA em danos intestinais recentemente observada em estudos pr&eacute;-cl&iacute;nicos. PEA&nbsp;<span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">&nbsp;</span>representa uma nova gama de abordagens terap&ecirc;uticas contra v&aacute;rios dist&uacute;rbios intestinais associados ao aumento da permeabilidade intestinal, incluindo doen&ccedil;a inflamat&oacute;ria intestinal e a isquemia intestinal aguda associada a choque circulat&oacute;rio.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Endometriose: Dor p&eacute;lvica e qualidade de vida</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">A endometriose afeta aproximadamente 10&ndash;20% das mulheres em idade reprodutiva, causando dor e infertilidade. Al&eacute;m disso, esta doen&ccedil;a cr&ocirc;nica afeta de maneira importante a qualidade de vida, bem como a sa&uacute;de sexual e psicol&oacute;gica. Nos &uacute;ltimos anos, surgiram evid&ecirc;ncias experimentais e cl&iacute;nicas consider&aacute;veis para apoiar o envolvimento dos mast&oacute;citos na dor associada &agrave; endometriose. A PEA &eacute; uma amida de &aacute;cido graxo end&oacute;gena pertencente &agrave; fam&iacute;lia das etanolamidas de &aacute;cidos graxos, que desempenha um papel na resolu&ccedil;&atilde;o de processos inflamat&oacute;rios pela modula&ccedil;&atilde;o negativa da ativa&ccedil;&atilde;o dos mast&oacute;citos e pelo controle do comportamento da microglia.&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Outro elemento importante na fisiopatologia da endometriose &eacute; o estresse oxidativo, provavelmente envolvido no crescimento e ades&atilde;o das c&eacute;lulas endometriais na cavidade peritoneal e consequente aparecimento da doen&ccedil;a. O presente estudo mostra que o tratamento com palmitoiletanolamida ultra micronizado (umPEA) seguido de palmitoiletanolamida / polidatina co-micronizada m(PEA / PLD) em pacientes com endometriose sintom&aacute;tica leva a uma redu&ccedil;&atilde;o significativa na intensidade dos sintomas dolorosos e melhora na qualidade de vida e bem-estar psicol&oacute;gico. O estudo indica a efic&aacute;cia e seguran&ccedil;a de um-PEA no tratamento da sintomatologia da endometriose.&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Sua administra&ccedil;&atilde;o a pacientes que n&atilde;o estavam recebendo nenhuma terapia padr&atilde;o proporcionou uma melhora significativa nos sintomas de dor, na qualidade de vida e no bem-estar psicol&oacute;gico. Dada a sua efic&aacute;cia e aus&ecirc;ncia de eventos adversos, PEA&nbsp;<span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">&nbsp;</span>pode ser uma estrat&eacute;gia terap&ecirc;uticas promissora para o tratamento da sintomatologia da endometriose, em particular para pacientes que n&atilde;o podem receber terapia hormonal ou que desejam engravidar.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Controle da Dor p&oacute;s-atividade f&iacute;sica intensa</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Um dos mecanismos para o est&iacute;mulo da s&iacute;ntese proteica e hipertrofia s&atilde;o as micro les&otilde;es musculares que ocorrem em treinos de for&ccedil;a. Essas micro les&otilde;es tamb&eacute;m acarretam inflama&ccedil;&atilde;o e dor que podem desencadear efeitos negativos como a vontade de n&atilde;o treinar no dia seguinte e a incapacidade de atingir a performance total. Os efeitos da suplementa&ccedil;&atilde;o com PEA&nbsp;<span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">&nbsp;</span>na redu&ccedil;&atilde;o da inflama&ccedil;&atilde;o e da dor podem auxiliar numa recupera&ccedil;&atilde;o mais r&aacute;pida da musculatura em treinos de for&ccedil;a melhorando a performance atl&eacute;tica.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">&nbsp;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Melhora da Recupera&ccedil;&atilde;o Muscular</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Pouco foi desvendado sobre o potencial do PEA na dor muscular cr&ocirc;nica em humanos. Um estudo investigou os n&iacute;ve</p>