PEA (Palmitoiletanolamida)

<p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><span style="font-size:22px;"><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; line-height: 1.5; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline; font-family: var(--q-font-primary) !important;">PEA Palmitoiletanolamida</span></u></span></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">A palmitoiletanolamida (N-Palmitoiletanolamida ou PEA) é uma amida de ácido graxo endógena pertencente à classe da N-aciletanolamida (NAE) de moléculas sinalizadoras, produzida a partir da bicamada lipídica e também está presente em alimentos como ovo e o amendoim. A descoberta dessa classe ocorreu na década de 1940, quando pesquisadores suplementaram a dieta de crianças carentes com gema de ovo em pó, prevenindo assim a febre reumática. Porém, somente em 1957 a palmitoiletanolamida foi isolada e teve comprovada sua ação anti-inflamatória. </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Contudo, foi na década de 1990 que seu mecanismo de ação foi elucidado, quando foi proposto que a PEA seria uma substância reguladora endógena do processo inflamatório, rendendo um Nobel de Medicina para o grupo de Rita Levi-Montalcini. O sistema endocanabinoide, do qual PEA faz parte, é formado por mediadores endógenos e pelos receptores de membrana celular, presentes em grande quantidade no sistema nervoso central, surgiu recentemente como uma nova estratégia terapêutica para o manejo da dor crônica. </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Estudos demonstraram a eficácia no tratamento da dor crônica de origem neuropática e inflamatória, dessa forma introduzindo uma nova alternativa na terapia analgésica e anti-inflamatória. Atualmente diversos estudos clínicos demonstram o potencial terapêutico da PEA no tratamento da dor e da inflamação, especialmente em processos crônicos degenerativos.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Os efeitos anti-inflamatórios e analgésicos são dose-dependentes e têm sido confirmados em modelos de inflamação crônica e dor neuropática. Nesses modelos o tratamento não apenas reduziu a dor, mas também preservou a morfologia periférica do nervo, reduziu o edema endoneural, o recrutamento e ativação de mastócitos e a produção de mediadores inflamatórios no local da lesão. Esses dados indicam que PEA pode agir como um agende modificador da doença. Um crescente número de estudos clínicos confirmam que PEA proporciona o alívio da dor em diferentes condições de dor crônica.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Evidências Clínicas no Manejo da Dor</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Nas triagens clínicas avaliando a eficácia e segurança, a administração foi realizada por períodos variando entre 14 e 120 dias, com doses variando entre 300 e 1200 mg ao dia. A forma mais comum de avaliação foi a VAS (Visual Analogue Scale), em que o paciente faz uma avaliação subjetiva do nível de dor em uma escala variando de ausência de dor até a pior dor imaginável.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Conclusões: <span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"> </span>Os resultados de todas as triagens clínicas, envolvendo no total, cerca de 6.000 pacientes demonstraram a redução da intensidade de dor e a ausência de efeitos adversos. Portanto, PEA representa uma nova estratégia terapêutica no manejo da dor crônica e dor neuropática associada com a neuroinflamação, geralmente bem tolerado nas populações pesquisadas, sem nenhum efeito adverso específico reportado.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Doenças Neurodegenerativas</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"> </span>A maior parte das pesquisas com PEA está relacionada ao manejo da dor e condições inflamatórias periféricas, enquanto ainda são muito poucas pesquisas com objetivo de avaliar possíveis efeitos benéficos em patologias relacionadas ao SNC.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Doença de Alzheimer</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Estudos pré-clínicos têm demonstrado que o PEA pode ser um potencial agente terapêutico em doenças que provocam neurodegeneração. Tem demonstrado potencial efeito neuroprotetor em modelos de Doença de Alzheimer (DA). A neuroinflamação e a disfunção sináptica em DA tem sido originalmente considerada um epifenômeno com inflamação e alteração na neurotransmissão, ocorrendo quando neurônios danificados provocam alterações na glia e mudanças na biologia neuronal. </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Atualmente está claramente estabelecido que a fisiopatologia da DA inclui também interações com mecanismos imunológicos no SNC. A neuroinflamação na DA está predominantemente relacionada com a microglia e astroglia residentes no SNC e com macrófagos perivasculares. As respostas inflamatórias regionais caracterizam o SNC na DA, com depósito de <span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: Symbol; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">b</span>-amiloide associada com o aumento da expressão de citoquinas pró-inflamatórias, proteínas de fase aguda e componentes do complemento, com sinais de microglia ativada e astrócitos reativos. </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">De acordo com este cenário, estudos neuropatológicos em cérebros humanos, demonstrando a ativação das células gliais, principalmente microglia e astrócitos, tem corroborado com estudos da DA em modelo animal nos quais a superprodução de sinais pro-inflamatórios pelas células gliais deflagra a cascata neurodegenerativa. Por outro lado, evidências indicam que também o estresse oxidativo e a disfunção sináptica são eventos precoces na DA.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Assim a neuroinflamação, o estresse oxidativo e a disfunção sináptica são partes integrantes da patogênese da DA. Neste contexto, a sinalização endocanabinoide e compostos canabinomiméticos tem demonstrado modular os principais processos patológicos durante fase precoce da DA, como desnaturação de proteínas, neuroinflamação, disfunção mitocondrial e estresse oxidativo. Entre estes compostos, PEA tem atraído muita atenção porque exerce uma função local anti lesão através da modulação negativa de mastócitos e protege neurônios de excitotoxicidade por vários mecanismos. </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Os achados descritos aliados aos mecanismos celulares e moleculares descobertos e descritos na última década sugerem fortemente que PEA ® poderia exercer promissoras funções protetoras contrapondo a neuroinflamação e neurodegeneração. A habilidade de PEA de interagir sinergicamente por vários mecanismos é atribuída as propriedades únicas deste ingrediente nutracêutico em relação a outros fármacos anti-inflamatórios convencionais. Não existem ainda dados clínicos sobre os efeitos benéficos de PEA em DA, porém em um estudo de caso, um paciente de 67 anos com distúrbio cognitivo moderado foi tratado com doses altas por 9 meses, com 3 meses de tratamento já apresentou melhora no quadro e com 9 meses estava praticamente normal.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Doença de Parkinson</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Um estudo clínico com 30 pacientes com Parkinson utilizando Levodopa, passaram a receber PEA <span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"> </span>na dose de 600 mg ao dia em associação e após 1 ano demonstraram significativa redução na progressão da doença e na incapacidade física.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Depressão</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">A maioria dos antidepressivos apresentam um limitado índice de resposta e um importante atraso no estabelecimento da ação, por esses motivos é uma área de constantes pesquisas de novos alvos farmacológicos antidepressivos. Evidências pré-clínicas têm demonstrado que o sistema endocanabinóide tem importante papel na modulação do humor e resposta ao estresse. O nutracêutico PEA tem como alvos farmacológicos não apenas o receptor PPAR-alfa, mas também o GPRR55, um receptor canabinóide não CB1 / CB2, pertencente ao sistema endocanabinóide. O PEA endógeno encontra-se aumentado em situações de estresse e em um estudo clínico randomizado, a suplementação de PEA <span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"> </span>em associação a terapia com Citalopram, indicou o estabelecimento da ação antidepressiva mais rápido no grupo com a adoção do nutracêutico. Este resultado demonstra efeito antidepressivo promissor de PEA <span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"> </span>embora mais estudos sejam necessários para o estabelecimento de seu potencial como modulador de humor e biomarcador de depressão.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Coadjuvante no Transtorno do Espectro do Autista (TEA)</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">A inflamação assim como a excitotoxicidade do glutamato tem sido considerada pela participação na propagação do transtorno do espectro autista (TEA). PEA <span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"> </span>é um endocanabinóide que previne a toxicidade glutamatérgica e também inibe a resposta inflamatória. Khalaj M. e colaboradores, publicaram em 2018 um primeiro estudo clínico randomizado, duplo-cego, placebo-controlado em grupo-paralelo, realizado por com 70 crianças com idades entre 4 e 12 anos com sintomas moderados a severos de irritabilidade que avaliou a associação de PEA na dose de 600 mg 2 vezes ao dia, ao tratamento estabelecido com Risperidona, por 10 semanas. </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Os resultados demonstraram significativa melhora no grupo utilizando a PEA associado em comparação ao grupo controle, especialmente nos parâmetros de irritabilidade e hiperatividade. De acordo com o estudo de Aron A. e colaboradores, publicado em 2019, foi observado níveis mais baixos de endocanabinoides como AEA, OEA (N-oleoiletanolamina), e PEA em amostras de soro de 93 crianças com TEA em comparação com amostras de neurotípicos correspondentes ao grupo controle. </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> Essas descobertas estão de acordo com os resultados de numerosos estudos anteriores em modelos animais de TEA e estudos iniciais em humanos. Recentemente em 2021, Colizzi M. e colaboradores publicaram a primeira revisão sistemática de todos os estudos que exploram os correlatos biocomportamentais do PEA no transtorno do espectro do autismo (TEA) em humanos e animais. Como resultado da suplementação de PEA em humanos como monoterapia e terapia adicional à medicação antipsicótica demonstrou reduzir a gravidade geral do autismo melhorando a linguagem expressiva (o que a criança diz) e fala inadequada (como a criança fala), além de modular o comportamento atípico e a resposta imune. </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Da mesma forma, a suplementação de PEA em diferentes modelos animais de autismo e condições relacionadas foi sugerida como eficaz na melhoria de comportamentos sociais e não sociais, bem como na modulação de uma série de processos neurobiológicos, incluindo neuroinflamação, neurotrofia, apoptose, neurogênese, neuroplasticidade, neurodegeneração, função mitocondrial e atividade da microbiota. Possivelmente essas respostas ocorrem através da ativação do PPAR-&alpha;</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Permeabilidade intestinal</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">PEA modula a permeabilidade intestinal em condições normais e condições inflamatórias. PEA diminui a permeabilidade, ou seja, aumenta a resistência via PPAR-&alpha;. Os níveis celulares de PEA é aumentado nas células epiteliais intestinais em resposta à inflamação, o que pode limitar o aumento da permeabilidade associada à inflamação. Os efeitos benéficos sobre a permeabilidade intestinal podem, pelo menos parcialmente, fundamentar o efeito protetor da PEA em danos intestinais recentemente observada em estudos pré-clínicos. PEA <span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"> </span>representa uma nova gama de abordagens terapêuticas contra vários distúrbios intestinais associados ao aumento da permeabilidade intestinal, incluindo doença inflamatória intestinal e a isquemia intestinal aguda associada a choque circulatório.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Endometriose: Dor pélvica e qualidade de vida</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">A endometriose afeta aproximadamente 10&ndash;20% das mulheres em idade reprodutiva, causando dor e infertilidade. Além disso, esta doença crônica afeta de maneira importante a qualidade de vida, bem como a saúde sexual e psicológica. Nos últimos anos, surgiram evidências experimentais e clínicas consideráveis para apoiar o envolvimento dos mastócitos na dor associada à endometriose. A PEA é uma amida de ácido graxo endógena pertencente à família das etanolamidas de ácidos graxos, que desempenha um papel na resolução de processos inflamatórios pela modulação negativa da ativação dos mastócitos e pelo controle do comportamento da microglia. </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Outro elemento importante na fisiopatologia da endometriose é o estresse oxidativo, provavelmente envolvido no crescimento e adesão das células endometriais na cavidade peritoneal e consequente aparecimento da doença. O presente estudo mostra que o tratamento com palmitoiletanolamida ultra micronizado (umPEA) seguido de palmitoiletanolamida / polidatina co-micronizada m(PEA / PLD) em pacientes com endometriose sintomática leva a uma redução significativa na intensidade dos sintomas dolorosos e melhora na qualidade de vida e bem-estar psicológico. O estudo indica a eficácia e segurança de um-PEA no tratamento da sintomatologia da endometriose. </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Sua administração a pacientes que não estavam recebendo nenhuma terapia padrão proporcionou uma melhora significativa nos sintomas de dor, na qualidade de vida e no bem-estar psicológico. Dada a sua eficácia e ausência de eventos adversos, PEA <span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"> </span>pode ser uma estratégia terapêuticas promissora para o tratamento da sintomatologia da endometriose, em particular para pacientes que não podem receber terapia hormonal ou que desejam engravidar.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Controle da Dor pós-atividade física intensa</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Um dos mecanismos para o estímulo da síntese proteica e hipertrofia são as micro lesões musculares que ocorrem em treinos de força. Essas micro lesões também acarretam inflamação e dor que podem desencadear efeitos negativos como a vontade de não treinar no dia seguinte e a incapacidade de atingir a performance total. Os efeitos da suplementação com PEA <span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"> </span>na redução da inflamação e da dor podem auxiliar numa recuperação mais rápida da musculatura em treinos de força melhorando a performance atlética.</p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""> </p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:=""><u style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;"><span style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: 600; font-stretch: inherit; font-size: inherit; line-height: 1.5; font-family: var(--q-font-primary) !important; font-optical-sizing: inherit; font-size-adjust: inherit; font-kerning: inherit; font-feature-settings: inherit; font-variation-settings: inherit; vertical-align: baseline;">Melhora da Recuperação Muscular</span></u></p> <p color:="" font-feature-settings:="" font-kerning:="" font-optical-sizing:="" font-size-adjust:="" font-variation-settings:="" helvetica="" style="box-sizing: inherit; -webkit-tap-highlight-color: transparent; margin: 0px; padding: 0px; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-variant-alternates: inherit; font-variant-position: inherit; font-variant-emoji: inherit; font-stretch: inherit; line-height: unset; font-family: roboto, Roboto, -apple-system, " vertical-align:="">Pouco foi desvendado sobre o potencial do PEA na dor muscular crônica em humanos. Um estudo investigou os níve</p>