Ácido Folínico

<p style="margin-bottom:11px"><span style="font-size:18px;"><span style="line-height:115%"><span style="font-family:Aptos,sans-serif"><span style="line-height:115%"><span style="font-family:&quot;Aptos Display&quot;,sans-serif"><span style="color:#0f4761">O &aacute;cido fol&iacute;nico (leucovorina) &eacute; uma forma ativa da vitamina&nbsp;B9 usada principalmente para reduzir a toxicidade de quimioter&aacute;picos (metotrexato) e potencializar o 5-fluorouracila (5-FU) no c&acirc;ncer. Atua diretamente sem precisar de convers&atilde;o metab&oacute;lica, sendo estudado tamb&eacute;m para melhorar comunica&ccedil;&atilde;o e comportamento no autismo (TEA), embora seu uso neste caso seja &quot;off-label&quot;.&nbsp;</span></span></span></span></span></span></p> <p style="margin-bottom:11px"><span style="font-size:18px;"><span style="line-height:115%"><span style="font-family:Aptos,sans-serif"><b><span style="line-height:115%"><span style="font-family:&quot;Aptos Display&quot;,sans-serif"><span style="color:#0f4761">Principais Usos e Indica&ccedil;&otilde;es:</span></span></span></b></span></span></span></p> <ul> <li style="margin-bottom:11px"><span style="font-size:18px;"><span style="color:#0f4761"><span style="line-height:115%"><span style="font-family:Aptos,sans-serif"><b><span style="line-height:115%"><span style="font-family:&quot;Aptos Display&quot;,sans-serif">Ant&iacute;doto de Quimioterapia:</span></span></b><span style="line-height:115%"><span style="font-family:&quot;Aptos Display&quot;,sans-serif">&nbsp;Neutraliza efeitos colaterais de antagonistas do &aacute;cido f&oacute;lico como o metotrexato.</span></span></span></span></span></span></li> <li style="margin-bottom:11px"><span style="font-size:18px;"><span style="color:#0f4761"><span style="line-height:115%"><span style="font-family:Aptos,sans-serif"><b><span style="line-height:115%"><span style="font-family:&quot;Aptos Display&quot;,sans-serif">Tratamento de C&acirc;ncer:</span></span></b><span style="line-height:115%"><span style="font-family:&quot;Aptos Display&quot;,sans-serif">&nbsp;Potencializa o efeito do 5-fluorouracila (5-FU) no tratamento de c&acirc;ncer colorretal</span></span></span></span></span></span></li> <li style="margin-bottom:11px"><span style="font-size:18px;"><span style="color:#0f4761"><span style="line-height:115%"><span style="font-family:Aptos,sans-serif"><b><span style="line-height:115%"><span style="font-family:&quot;Aptos Display&quot;,sans-serif">Transtorno do Espectro Autista (TEA):</span></span></b><span style="line-height:115%"><span style="font-family:&quot;Aptos Display&quot;,sans-serif">&nbsp;Estudos investigam seu uso em subgrupos com disfun&ccedil;&atilde;o metab&oacute;lica de folato, associando-o a melhorias na linguagem e intera&ccedil;&atilde;o social, mas&nbsp;<b>n&atilde;o &eacute; um tratamento padr&atilde;o</b>.</span></span></span></span></span></span></li> <li style="margin-bottom:11px"><span style="font-size:18px;"><span style="color:#0f4761"><span style="line-height:115%"><span style="font-family:Aptos,sans-serif"><b><span style="line-height:115%"><span style="font-family:&quot;Aptos Display&quot;,sans-serif">Anemias:</span></span></b><span style="line-height:115%"><span style="font-family:&quot;Aptos Display&quot;,sans-serif">&nbsp;Usado em casos de anemia megalobl&aacute;stica por defici&ecirc;ncia de folato.</span></span></span></span></span></span></li> </ul>